| Day | Week | Home | Result | Away |
|---|---|---|---|---|
| 2025-09-08 | 1 | Carl Zeiss Jena | 1 - 4 | Hoffenheim |
| 2025-09-14 | 2 | Hoffenheim | 3 - 0 | Eintracht Frankfurt |
| 2025-09-21 | 3 | Werder Bremen | 2 - 1 | Hoffenheim |
| 2025-09-24 | 4 | Hoffenheim | 1 - 1 | Nürnberg |
| 2025-10-06 | 5 | Hamburger SV | 1 - 4 | Hoffenheim |
| 2025-10-12 | 6 | Hoffenheim | 0 - 2 | Bayer Leverkusen |
| 2025-10-17 | 7 | SGS Essen | 0 - 1 | Hoffenheim |
| 2025-11-01 | 8 | Wolfsburg | 2 - 1 | Hoffenheim |
| 2025-11-06 | 9 | Hoffenheim | 2 - 1 | Freiburg |
| 2025-11-09 | 10 | Köln | 1 - 0 | Hoffenheim |
| 2025-11-23 | 11 | Hoffenheim | 1 - 5 | Bayern München |
| 2025-12-07 | 12 | Hoffenheim | 3 - 0 | Union Berlin |
| 2025-12-14 | 13 | RB Leipzig | 2 - 3 | Hoffenheim |
| 2025-12-20 | 14 | Hoffenheim | 5 - 1 | Carl Zeiss Jena |
Hoffenheim
2025-26シーズン